PUBLISHED WORK

2019

• Ting HC(丁修齊), Chen LT(陳力慈), Chen JY(陳若予), Huang YL(黃義澧), Xin RC(辛睿誠), Chan JF, Hsu YH. Double bonds of unsaturated fatty acids differentially regulate mitochondrial cardiolipin remodeling. Lipids Health Dis. 2019 Feb 14;18(1):53.

• Chang WH(張菀芯),  Liua PY, Jiang YT* and Hsu YH*. A Sensitive Chromatographic Method for Hyaluronate Quantification applied to analyze the desorption behavior on contact lenses. Current Pharmaceutical Analysis. 2019. Accepted.

2018

• Chang WH(張菀芯), Ting HC(丁修齊), Chen WW(陳韋維), Chan JF, Hsu YH*. Omega-3 and omega-6 fatty acid differentially impact cardiolipin remodeling in activated macrophage. Lipids Health Dis. 2018 Aug 28;17(1):201.

• Chen WW(陳韋維), Chao YJ(趙昱任), Chang WH(張菀芯), Chan JF and Hsu YH*. Phosphatidylglycerol Incorporates into Cardiolipin to Improve Mitochondrial Activity and Inhibits Inflammation. Scientific Reports. 2018 Mar 20;8(1):4919.

• Chao YJ(趙昱任), Wu WH(吳文馨), Balazova M, Wu TY(吳庭遠), Lin J, Liu Yi-Wen * and Hsu YH*. Chlorella Diet Alters Mitochondrial Cardiolipin Contents Differentially in Organs of Danio rerio Analyzed by a Lipidomics Approach. PLOS One. 2018 Mar 1;13(3):e0193042.

• Chou YT, Hsu FF, Hu DY, Chen YC(陳映志), Hsu YH, Hsu JT, Chau LY. Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity. J Biomed Sci. 2018 Jan 23;25(1):6

2017

•    Lo YT(羅伊婷), Huang HW(黃泓偉), Huang YC(黃翊銓), Chan JF and Hsu YH.* Elucidation of tRNA–Cytochrome c Interactions through Hydrogen/Deuterium Exchange Mass Spectrometry. BBA proteins and proteomics. 2017. May;1865(5):539-546.

2016

• Yang SW(楊勝惟), Ting HC(丁修齊), Lo YT(羅伊婷), Wu TY(吳庭遠), Huang HW(黃泓偉), Yang CJ, Chan JF, Chuang MC and Hsu YH.* Guanine Nucleotide Induced Conformational Change of Cdc42 Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry. BBA proteins and proteomics. 2016 Jan;1864(1):42-51.

• Chao YJ(趙昱任), Chan JF and Hsu YH*. Chemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin Fluctuation. PLOS One. 2016 Sep 14;11(9):e0162457.

2015

•    Ting HC(丁修齊), Chao YJ(趙昱任) and Hsu YH*. Polyunsaturated Fatty Acids Incorporation into Cardiolipin in H9c2 Cardiac Myoblast. J Nutritional Biochemistry. 2015 Jul;26(7):769-75.

2014

• Chao YJ(趙昱任), Chang WH(張菀芯), Ting HC(丁修齊), Chao WT and Hsu YH*. Cell Cycle Arrest and Cell Survival Induce Reverse Trends of Cardiolipin Remodeling. PLOS One. 2014 Nov 25;9(11):e113680.

• Lai YH, Liao YC, Mu JJ, Kuo TM, Hsu YH, Chuang MC. Biomolecular logic gate for analysis of the New Delhi metallo-β-lactamase (NDM)-coding gene with concurrent determination of its drug resistance-encoding fragments. Chem Commun (Camb). 2014 Oct 18;50(81):12018-21.

2013

• Cao J, Hsu YH, Li S, Woods VL Jr and Dennis EA. Structural Basis of Specific Interactions of Lipoprotein-Associated Phospholipase A2 with HDL Revealed by Hydrogen Deuterium Exchange Mass Spectrometry. J Lipid Res. 2013 Jan;54(1):127-33.

• Hsu YH, Bucher D, Cao J, Li S, Yang SW(楊勝惟), Kokotos G, Woods VL Jr, McCammon J, Dennis EA. Fluoroketone Inhibition of Ca2+-Independent Phospholipase A2 through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics. JACS 2013  Jan 30;135(4):1330-7.

• Hsu YH, Dumlao DS, Cao J and Dennis EA. Assessing Phospholipase A2 Activity toward Cardiolipin by Mass Spectrometry. PLoS One. 2013;8(3):e59267

• Bucher D, Hsu YH, Mouchlis VD, Dennis EA and McCammon J. Insertion of the Ca2+-Independent Phospholipase A2 into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations. PLOS Computational Biology. 2013 July; 9(7): e1003156

2012

• Yang SW(楊勝惟) and Hsu YH. Pak2. Encyclopedia of Signaling Molecules. 2012 1345-48 (Book Chapter)

• Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell, Sun W, Wang X, Hsu YH, Hughes G, Su Z, Zhang M, Esteve-Rudd J, Lopes VS, Williams DS, Molday RS, Shaw PX, Dennis EA, and Zhang K, Essential role of elovl4 in very long chain fatty acid synthesis and retinal function. J Biol Chem. 2012  Mar 30;287(14):11469-80

2011

• Cao J, Hsu YH, Li S, Woods VL Jr and Dennis EA. Lipoprotein-Associated Phospholipase A(2) Interacts with Phospholipid Vesicles via a Surface-Disposed Hydrophobic α-Helix. Biochemistry. 2011 Jun 14;50(23):5314-21.

• Hsu YH. PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2). Atlas Genet Cytogenet Oncol Haematol. April 2011. (Invited Review)

• Dennis EA, Cao J, Hsu YH, Magrioti V and Kokotos G. Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention.  Chemical Reviews. 2011 Oct 111:6130-85. SCI.

• Hsu YH, Traugh, JA. Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation. J. Vis. Exp. 2011 Nov.  (57), e3602

2010

• Hsu YH and Traugh JA. Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysis. PLoS One. 2010 Mar 1;5(3):e9455.

• Kokotos G, Hsu YH, Burke JE and Dennis EA. Potent and selective fluoroketone inhibitors of Group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10.

2009

• Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA and Kokotos G. 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43.

• Hsu YH, Burke JE, Li S, Woods VL Jr and Dennis EA. Localizing the membrane binding region of Group VIA Ca2+-independent Phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009 Aug 28;284(35):23652-61.

2008

• Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL Jr and Dennis EA. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2008 Apr 11;283(15):9820-7.

• Burke JE, Hsu YH, Deems RA, Li S, Woods VL Jr and Dennis EA. A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem. 2008 Nov 7;283(45):31227-36.

• Hsu YH, Johnson DA and Traugh JA. Analysis of conformational changes during activation of protein kinase Pak2 by amide hydrogen/deuterium exchange. J BiolChem. 2008 283(52):36397-405.

Before 2007